A quasi experimental study to assess the effect of facilitated tucking position on pain among infants receiving intramuscular immunization at selected hospital, Thrissur. The objective of the study was to assess the pain score among infants receiving intramuscular immunization in comparison and experimental group, evaluate the effect of facilitated tucking position on pain score among infants receiving intramuscular immunization in experimental group and associate the pain score among infants receiving intramuscular immunization with their selected demographic variables. The conceptual framework utilized in this study was kolkaba’s theory of comfort. Nonprobability purposive sampling technique was used to select the samples. Post-test only design was adopted to assess the effect of facilitated tucking position on pain score among 60 infants (30 in experimental and 30 in comparison group) undergoing intramuscular immunization who fulfilled the inclusion and exclusion criteria at Government General Hospital, Thrissur. The tool consists of semi structured questionnaire to assess the demographic variables of infants, includes age, gender, weight, height and time of last feed. Face Leg Anger Cry and Consolability (FLACC) Scale was used to assess the pain score of infants in experimental and comparison group. Reliability and validity of the tool was established. The pilot study was done for 6 subjects and found to be feasible. The main study was conducted from 2nd February to 3rd March 2019. Facilitated tucking was performed on the infants during intramuscular immunization and the pain score was assessed after the procedure and interpreted using FLACC Scale. The study findings revealed that Comparison of pain score in both groups that the calculated ‘t’ value was 7.22, where the table value was 2.390 at 0.001 level of significance. Thus, it was concluded that the facilitated tucking was effective in reducing pain during intramuscular immunization. There was no xii statistically significant association between the pain score among infants receiving intramuscular immunization with their selected demographic variables. Nurses can practice facilitated tucking as a part of routine nursing care of infants during painful procedures. Keywords: Facilitated Tucking Position; Pain Score; Infants; FLACC scale.