Natural products have historically been a rich source of biologically active compounds for drug discovery (Schiff et al,1979). Tocotrienols are vitamin isomers which are “essential” meaning they cannot be manufactured by the human body. Hence they have to be obtained from food and supplements. In nature they occur in four different forms: a, b, g, and ä   Tocotrienols. Palm oil, one of the richest sources of Tocotrienols, is an ideal source since it contains more of the, g and ä than a, b- Tocotrienols. Taken orally, tocotrienols are bio available to all vital organs. Tocotrienols have wide ranging clinical effects with anticancer, radioprotective, anti hypercholesterolemic,  antiangiogenic, antioxidant, anti-inflammatory, antineurodegenration and antimicrobial properties. A safe and effective therapy for radiation injuries as well as cancer prevention is the need of the hour. Analytical and clinical study on Tocotrienols may prove vital for life. The main objective of this review study is to highlight clinical potential significance of the tocotrienols in health and diseases as a therapeutic supplement.