A common treatment for both acute and chronic wounds is negative pressure wound therapy. NPWT is recommended for a range of difficult wounds, and certain research support its usage in specific burn care procedures. Even though more study is required to fully understand the advantages for burns, NPWT has shown promise as a dressing that supports skin grafts, encourages the integration of laminate dermal substitutes, encourages the re-epithelialization of skin graft donor sites, and may even lessen the zone of stasis. Based on indication/application, this article analyses the literature on NPWT in burns and discusses our experience with modified NPWT for major burns