Background of the study: Cervical cancer is the one of the most common cancer in women. Human papilloma virus (HPV) is the primary cause of cervical, anal, vulva, vaginal and penile cancers as well as genital warts. The quality of life of cervical cancer patients has captivated more and more attention. The quality of life at different clinical stages before and after therapy in order to provide and after therapy in order to provide evidence for preventing and treating cervical carcinoma1. Non-experimental study was carried out to assess the quality of life among women with cervical cancer, in radiation oncology department, SVIMS, Tirupati, Andhra Pradesh. Data was collected from 100 women, taking radiation oncology treatment in radiation oncology department, SVIMS, Tirupati. Significant findings in the study revealed that among 100 women 38% (38) shows moderate level of quality of life, 25% (25) had low level of quality of life, 37% (37) had high level of quality of life. There is a significant association between level of quality of life among women with cervical cancer with menstrual history, no. of children, no. of fractions at p < 0.01 level. Age, family income, religion, type of surgery were associated at p < 0.05 level. The conclusion suggest that the women’s having moderate level of quality of life receiving radiotherapy. The nurses in the hospital should workout a plan for educational programs based on their level of knowledge regarding quality of life among women with cervical cancer.