Background: Hypertension is a major chronic lifestyle disease affecting one in three adults over 25 years or about one billion, thereby resulting in cardiovascular, cerebrovascular, and renal complications. In addition, it is an important contributor for increased cardiovascular morbidity and mortality in industrialized countries. Reports suggest that hypertension is rapidly increasing in the developing countries like India. Although medical management is effective in treating hypertension, owing to the side effects, alternative therapy such as Yoga practice is recommended. However, evidences on the efficacy of yoga practice in patients with hypertension are insufficient and further research is required. Objective: The study aimed to investigate the effectiveness of a Yoga program on Stress and Anxiety in patients with hypertension. Methods: Of 238 patients, 118 were randomly assigned to participate in yoga program (YP) group and 120 to the control group (CG) with no treatment. Parameters such as blood pressure (BP), anxiety, and perceived stress were measured before and after intervention. Results: The groups were initially homogeneous; however, after intervention, the groups significantly differed. The YP group exhibited reduced BP, anxiety, and perceived stress (5 < 0.001). Conclusion: he study suggests that yoga program may offer an effective intervention in reducing BP, anxiety and perceived stress in patients with hypertension. Practicing Yogaasanas at homeare helpful to avoid increased BP­related complications.