Introduction: World Health Organization estimates disclose that 1 in 10 health care workers (HCWs) worldwide sustain a needle stick injury each year. The risk of infection due to needle stick injuries (NSIs) varies from 0.5% to 40% for HIV and HBV infections, respectively. Globally, there is gross under-reporting of NSIs with the actual incidence of NSIs being much higher than those reported.

Methodology: A quantitative research approach with one group pretest posttest design was used to assess the effectiveness of teaching program on knowledge regarding prevention and management of needle stick injury among staff nurse in a selected Hospital in Ajman, UAE. Data were obtained from 68 staff nurses by using a convenient sampling technique. Permission was sought from the hospital management and informed consent was taken from the participants. On 14th day after the teaching program, posttest was conducted for all the participants. The collected scores were tabulated and entered in the excel sheet and further analyzed by using SPSS statistical package.

Results: The result shows that 79% of the staff nurses had adequate level of knowledge and only 21% had moderate level of knowledge. None of the staff nurses had poor knowledge regarding needle stick injury. After teaching program 97% of the staff nurses had adequate level of knowledge and only 3% had moderate level of knowledge. None of the staff nurses had poor knowledge regarding needle stick injury. Structured teaching program on needle stick injury was found to be effective at P (0.002). No association was found with any of the selected demographic variables.

Conclusion: The findings of the study revealed that the structured teaching program could make a significant improvement in knowledge level of staff nurses. The study highlights the need for conducting similar awareness programs regarding prevention and management of needle stick injuries among healthcare professionals.