Parental fear and anxiety arise mostly due to lack of knowledge about disease, treatment associated with cancer. The parents of children who undergo chemotherapy are informed about the all the methods and side effects of chemotherapy.

Objectives of the Study: 1.To assess knowledge of parents regarding chemotherapy before and after administration of self-Instructional module. 2. To assess the effectiveness of self-instructional module on knowledge regarding chemotherapy.

Methods: A quantitative research approach with pre-experimental design was used for the study. The study was conducted at selected hospital in Surat. The sample comprised of 30 parents whose children are undergoing chemotherapy. Sample was selected by using non-probability purposive sampling technique. Formal written permission from hospital authorities was obtained prior to data collection prosses. Data was collected using a self-structured questionaries’.

Result: The result of the study showed that highest percentage (53.33%) of parents were in the age group of 28-30 years. Knowledge score of parents regarding chemotherapy showed that pre-test knowledge score with the pre-test mean score of (7.56%), Whereas the post-test knowledge score with a mean of (16.36%).