This Intestinal worm infestations are widely prevalent in tropical and subtropical countries and occur where there is poverty and poor sanitation. The child to child approach is an educational process that links children learning with fusion action to promote the health wellbeing and development of themselves their families and their communities. The objective of the present study is to evaluate the effectiveness of the Child to Child approach on the prevention and management of worm infestation among school children in the changeset, Kancheepuram district, Tamil Nadu. Quantitative approach and pre-experimental one group pretest, posttest design was adopted based on the inclusion and exclusion criteria. The total number of 100 children were selected by the non–probability convenient sampling technique. The tool used for the study comprises two sections section A and Section B. Section A comprised of demographic data which includes age, gender, siblings. Occupation of mothers, Toilet facilities, water facilities. Section B comprises a structured questionnaire that was developed by the researcher to assess the knowledge on Prevention and management of worm infestation among school students which includes forty questions to answer the questionnaire. The results of the study are before giving Child to Child approach in the value of which is pretest level of knowledge showed that 50 (50%) students have inadequate knowledge and 50 (50%) students have moderately adequate knowledge none of them have adequate knowledge. After giving the Child to Child approach the level of knowledge showed that 22(22%) students have moderately adequate knowledge 78(78%), students have adequate knowledge none of them have inadequate knowledge The investigator found that Child to Child approach in improving the level of knowledge on prevention and management of worm infestation. (t=31.15; p=0.0001).