Background: TB is a worldwide public health problem that is closely associated with poverty, malnutrition, overcrowding, substandard housing, and inadequate health care. Mortality and morbidity rates continue to rise; Mycobacterium Tuberculosis infects an estimated one third of the world’s populations and remains the leading cause of the death from infectious disease in the world. According to WHO, an estimated 1.6 million deaths resulted from TB in 2005 (WHO, 2007). In 2005 there were 14, 093 reported cases of TB in the United States, a 3.8% decline from the previous year. However, two prevalent public health concerns remain about TB. First is the increase in the number of TB cases attributable to multi-drug resistant organisms (MDR-TB) and extensive drug-resistant organisms (XDR-TB). These forms of TB have been found worldwide and a threat to public health as a potential epidemic that is considered practically untreatable. Objective: To assess the factors contributing to noncompliance with tuberculosis treatment among tuberculosis patients in selected areas of the city. Methodology: A Non experimental study with descriptive research design is used among 100 Tuberculosis patients with noncompliance to tuberculosis treatment in selected areas of the city and are available at the time of data collection. The Purposive sampling technique is used. Data was collected on total four factors contributing to noncompliance these are patient related factors, health system related factors, disease and medicine related factors and socioeconomic related factors. The collected data was coded, analysed by using descriptive statistics and inferential statistics. Result: As perpatient related factors to noncompliance revels that majority of participants have knowledge regarding Antituberculosis drugs, which is given by health care worker. As per health care system related factors data revels that health care facilities are easily available and convenient for them. As per disease and medicine related factors data revels that all participant experience drug related side effect, these are nausea & vomiting & loss of appetite. All participants responded they did not feel better throughout the Antituberculosis treatment therapy. As per socioeconomic related factors data revels that majority of participant had financial problem as their job & salary affected because of illness & treatment. So majority of participant stopped Antituberculosis treatment. Conclusion: Non-compliance was found to be influenced by multiple factors like experiencing different side effects of Antituberculosis treatment, not feeling better throughout therapy, fear of social isolation and impact on job & salary which finally affect socioeconomic condition.