AbstractBackground: Instead of gonadotropins, laparoscopic ovarian drilling is considered an alternative method to induce ovulation in polycystic ovary syndrome. Aim: This study is a prospective study to compare the efficacy of ULOD versus BLOD in clomiphene citrate resistant patients in terms of ovulation and pregnancy rates. Materials and Methods: This study was a prospective, parallel randomised clinical trial which was conducted between May 2010 to June 2011. 110 PCOS patients with CC resistance were allocated randomly into ULOD (Group I) and BLOD (Group II) Results: A total of 110 patients with PCOS who underwent LOD were included. These patients were divided equally in two groups of ULOD and BLOD. Between two groups, baseline characteristics difference of patients prior to laparoscopy were not significant (p>0.05). No significant differences were observed in clinical and biochemical responses also. In both groups, after drilling, LH and testosterone levels mean serum concentrations were decreased. Between two groups, the mean decrease in serum LH and testosterone concentrations levels were not statistically significant. Conclusion: In ovulation and pregnancy rates, ULOD seems to be equally efficient as BLOD.