Introduction: Prelabour rupture of membrane complicates pregnancy affecting delivery route and course of labour. This study aims at comparison of oral misoprostol and oxytocin infusion for labour induction in term PROM.

Objective: To compare efficacy and safety of oral misoprostol with oxytocin infusion for induction of labour in term PROM.

Methods: The study is retrospective study carried on 100 pregnant women admitted in department of OBGY, ACPM medical College, Dhule from June 2015-June 2017. The women were assigned randomly to anyone of 2 equal groups. Group A received 25 micrograms of misoprostol every 4 hrs for maximum of 4 doses. Group B received oxytocin infusion primigravida 2 IU diluted in IV fluid and multigravida with 2.5 IU diluted in IV fluid with maximum dose of 5 IU in primigravida and 2.5 IU in multigravida. The primary
outcome was induction delivery interval. The secondary outcomes were mode of delivery, maternal and neonatal outcomes.

Results: The study showed that mean induction delivery interval was significantly lower (5.6hrs) in misoprostol group as compared to oxytocin  group (7.2hrs). In misoprostol administered group 78% patients delivered by vaginal route while in oxytocin group it was 70% whereas
22% required Caesarean Section in misoprostol group while it was 30% in oxytocin group. Incidence of hypertonus was higher (22%) in misoprostol group as compared to oxytocin group (10%).

Conclusion: In our study, the time intervals from induction to delivery were significantly shorter in misoprostol group than oxytocin group. Meconium stained liquor was seen more in women induced with misoprostol group than oxytocin. Intravenous oxytocin is still an effective option.

Keywords: Induction of Labour; Misoprostol, Oxytocin; Premature Rupture of Membranes.