Abnormal uterine bleeding is a common gynecological clinical problem. In premenopausal age uterine leiomyomata are the common cause and among the postmenopausal women the concern is endometrial carcinoma. Ovarian steroidal hormones do stimulate cell proliferation and extracellular matrix accumulation initiating or promoting growth of leiomyocyte. It is known that ovarian hormones are dependent on receptors for exerting their action. Leiomyoma grow even in patients with no increased estrogen. Whereas, endometrial carcinoma is an ovarian hormone dependent tumor with a subtype more often attributed to an unopposed estrogenic stimulation of endometrium. Reported are 4 cases in premenopausal age that were detected to have developed endometrial carcinoma in short time after the myomectomy.

Keywords: Leiomyoma; Endometrial Carcinoma; Premenopausal Women; Nulligravida; Abnormal Uterine Bleeding