Context:  125 million people worldwide 2 to 3 percent of the total population-have psoriasis. Psoriasis prevalence in African Americans is 1.3%compared to 2.5% percent of Caucasian12. Aims: To study the socio demographic profile and disease characteristics in a psoriasis. Settings and Design: Cross Sectional Study. Methods and Material:The study comprised of total 417 cases of psoriasis vulgaris. According to body surface area involvement disease was graded as mild moderate and severe.  Metabolic syndrome was diagnosed and .Dermatology life quality index was evaluated. Out of 417 psoriasis patients,90 patients with psoriasis were randomly selected and divided in 3 groups. PASI score was evaluated at baseline and then at every follow up of 2 weeks, 4 weeks and 6 weeks. Results:Psoriasis is more common in males.49.96% of male patients were involved in farming and manual work.31.65% patients were smokers. Most common site was lower limb (94.72%). Nail changes were present in 79.85% and Arthiritis was present in 11.99% of patients. Prevalence of obesity was more in females (26.86%). No significant difference was observed in prevalence of type 2 diabetes or hypertension or obesity. There was a positive association of hypertriglyceridemia with psoriasis. Quality of life is definitely greatly impaired by psoriasis as DLQI was hugely affected in 26.85% of patients and moderately affected in 36.58% of patients. Calcitriol ointment (0.0003%) had very effective role in keeping the disease under remission and has moderate response compared to clobetasol propionate (0.05%) cream. Conclusions: Psoriasis is associated with several comorbidities and can have a significant impact on a patient's quality of life.

 Keywords: Psoriasis; DQLI; Metabolic Syndrome.