Background and Objectives: Portal hypertension (PHT) commonly accompanies cirrhosis of liver. Development of esophageal varices is one of the major complications of PHT. Present study was performed with objectives to study clinical profile of patients admitted with liver cirrhosis, to study endoscopic findings of patients having portal hypertension and liver cirrhosis and to study hematological abnormalities associated with liver cirrhosis and its correlation with endoscopic findings. Material and Methods: A retrospective study was conducted at tertiary care centre over the period of 7 months which includes 40 patients with liver cirrhosis and portal hypertension and who had undergone gastroduodenoscopy. Study variable were anemia, thrombocytopenia, leucopenia. Esophageal varices were grades according to Westaby and colleagues grading system proposed in 1984, based on the luminal occupancy of esophageal varices, which has been endorsed by the British Society of Gastroenterology in its guidelines. Results: The most common hematological abnormality was prolongation of prothrombin time followed by anemia. Leucopenia was the least common while thrombocytopenia was present in more than half of the patients. The age range was from 16 to 80 yrs. with mean age of 44.2 years. Most common finding on clinical examination was pallor followed by splenomegaly. Conclusion: The Cirrhotic patients with normal hemoglobin or only mild anemia can be closely followed up and wait for endoscopy being at a low risk for variceal bleeding, especially in financially deprived countries andresource limited setting.