Aims and objective: Poisoning is a major problem all over the world, although its type and the associated morbidity and mortality vary from country to country. The nature of poison used varies in different parts of the world and may vary even in different parts of the same country depending on the socioeconomic factors and cultural diversity. We conducted this study to see clinical spectrum and in hospital-mortality of acute poisoning cases among adults presenting to our emergency. Material and methods: This prospective study was conducted in patients of acute poisoning admitted in the emergency wing of our hospital. A total of 540 patients fulfilled inclusion criterion. Cases were reviewed prospectively by a specially designed data collection form which was used to collect the detail of patient’s age, sex, type of poison, method/mode of poisoning and in-hospital mortality among acute poisoning cases either referred or reported directly. Results: Out of 540 patients in the study, 315 were male and 225 were female, most cases of acute poisoning comprised of young population ranging from 16 to 35 years, majority of cases were from urban areas and were married. Majority of patients were educated and were students. Circumstances leading to acute poisoning were intentional in majority. Route of administration was oral in 98%. A total of 52 people died due to acute poisoining with case fatality rate of 9.63%. Conclusion: Acute Poisoning is not uncommon in our region. Mostly young peoples are victims of poisoning. Establishment of a poison control center in the region will help in preventing and controlling such poisoning events.