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DOI: DOI: http://dx.doi.org/10.21088/ijem.2395.311X.4418.3

Abstract

  Background: The cause of idiopathic focal segmental glomerulosclerosis is usually not known. Most of the patients present with primary type. The main clinical feature of FSGS is nephrotic syndrome. It causes about 10 to 15% of cases of nephrotic syndrome. Its increased incidence and high rate of progression to end stage renal disease makes it us an important disease for present study. Method: Thirty five patients of biopsy proven idiopathic FSGN with biochemical and hisptopathological data have been included in this study. All patients were treated on outpatient/inpatient basis. All patients were subjected to detailed general and systemic examination. Patients who had a minimum follow up of 3 months were included in the study. Result: Males are affected more frequently than females. Males were 26 (74%) and females were 9 (26%). The most common presentation was nephritic syndrome in 27 (77%), and clinical feature was proteinuria, in all the patients, hypertension in 16 patients (46%), and hematuria in 16 patients
(46%). 16 patients (46%) progressed to renal failure over a period of 1 to 6 years. Conclusion: Nephrotic range (Nephritic) Proteinuria is the main clinical feature. Response to steroids is variable and unpredictable. Prognosis is better in steroid responsive as compared to non – responsive patients. 

Keywords: Idiopathic Focal Segmental Glomerulosclerosis; Nephritic; Proteinuria; Renal Failure.

Corresponding Author : Vishwas N. Jeurkar, Assistant Professor, Department of General Medicine, Ashwini Rural Medical College, Hospital & Research Centre, Kumbhari, Solapur, Maharashtra 413006, India.