Guillain-Barré syndrome (GBS) is an acute fulminant polyradiculoneuropathy that is autoimmune in nature. It manifests as a rapidly evolving areflexic motor paralysis with or without sensory disturbance. Weakness typically evolves over hours to a few days and is frequently accompanied by tingling dysesthesias in the extremities. Approximately 70% of cases of GBS occur 1-3 weeks after an acute infectious process. Although GBS is considered to be monophasic, recurrences are reported in 2–5% of patients [1,2]. We describe a case of 20 year old male who presented with ascending limb weakness along with difficulty in swallowing and speaking since 12 hours. He further developed respiratory failure requiring mechanical ventilator support and was diagnosed as a case of Guillain-Barre syndrome. Patient had history of similar episode 15 years back for which he was hospitalized for 4 months and had complete recovery.

Keywords: Ascending Weakness; Immune Response; Peripheral Neuropathy; Respiratory Failure; Recurrent Guillain-Barre Syndrome.