Dengue is one of the leading causes of mortality amongst seasonal arboviral diseases in the Indian subcontinent. The Clinical manifestations of dengue vary from mild febrile illness to life threatening dengue shock syndrome with polyserositis and severe hemorrhagic tendencies. There is also a variability in presentation in different areas of endemicity and between specific age groups. whereas predictors of outcome have remained controversial. To understand the antibody responses to dengue nonstructural 1 (NS1) glycoprotein and its role in protective immunity or pathogenesis of dengue fever (DF) and dengue hemorrhagic fever (DHF), we have analysed the NS1-specific IgM, from patients with DF and DHF. The morbidity and mortality of DHF can be reduced by early hospitalization and careful supportive care. Circulating NS1 has been detected in acute-phase serum samples of patients with DV infections. The goals of this study were to determine whether plasma levels of NS1 correlate with severity of dengue in terms of shock, hemorrhagic manifestations, polyserositis, ARDS, need of intensive care and duration of hospital stay. In addition to the end result in terms of Mortality and residual disability.

Keywords: Antigen; Fever; Hypotension; Shock; Serology.