Background: Management of the patients presented with dyspnea can be challenging in emergency department(ED), because differentiating underlying cause can be difficult and time consuming. Point of care ultrasound(POCUS) examination in early evaluation of critical patients have been reported to be helpful in rapid diagnosis of causes of dyspnea which in turn helps in early Resuscitation. Aim: We performed this study to assess utility of POCUS in differentiating causes of dyspnea & compared with final diagnosis at the time of discharge/death. Settings and design: This was a single centre prospective diagnostic study to assess utility of POCUS in dyspnea. It was approved by ethical committee. Materials and methods: The study was conducted at ED of tertiary care government hospital in Central Gujarat from December 2018 to November 2019. All patients presenting with dyspnea to ED were included after written informed consent. Patients’ age < 12 years, Patients not willing for admission, and Patient who took discharge against medical advice /absconded/died before establishing final diagnosis were excluded. Provisional diagnosis made through POCUS was compared with the final diagnosis made by the consultants of respective clinical departments during course of their hospitalization. Statistical analysis and results: 146 patients with dyspnea presenting to ED were included in prospective observational study. True and False positives, sensitivity and specificity were calculated from the analysis of data. Reliability index was calculated on the basis of above data. *Conclusion: This study showed good efficacy of POCUS in differentiating causes of dyspnea when compared with final medical diagnosis. Thus POCUS helps in early resuscitation and management.