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Indian Journal of Emergency Medicine

Volume  5, Issue 4, October-December 2019, Pages 233-238

 

Original Article

Assessment of Short-term Electrocardiographic Changes Induced by Antibiotic Amoxicillin and Clavulanate
Shambhulinga Purad1, Jagadish Shisol2
1,2Assistant Professor, Department of General Medicine, Gadag Institute of Medical Sciences, Malasamudra, Gadag, Karnataka 582103, India.
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DOI: DOI: http://dx.doi.org/10.21088/ijem.2395.311X.5419.3

Abstract

Background and Objectives: Antibiotics are widely used for variety of infections. Drugs like Macrolides, Flouroquinolones can cause prolongation of the QT interval. The objective of this study was to assess the changes in 12 lead Electrocardiogram of patients receiving intravenous Amoxicillin and Clavulanate, parameters like heart rate and corrected QT interval (QTc) were analyzed. Methods: A total of 40 patients who received intravenous Amoxicillin and Clavulanate were enrolled in the study. Serial 12 lead surface Electrocardiogram were taken at 4 time points as follows. First ECG taken before the administration of the antibiotic. These were followed by a 10 minutes, 20 minutes and 60 minutes of infusion. The parameters of Electrocardiogram viz; Heart rate, QTc Interval were assessed. Results: In our study we found that there was mean increase in the heart rate of less than 2 beats per minute and mean increase in QTc interval of 9.6 ms at 60 minutes when compared to baseline. This difference was statistically signi cant but clinically not signi cant as the corrected QT interval was still within the normal range. Conclusion: Administration of antibiotics like Amoxicillin and Clavulanate, through intravenous route caused a minimal though statistically signi cant increase in heart rate and QTc at 60 minutes compared to baseline, in patients without cardiovascular disease or electrolyte disturbances. However the corrected QT intervals remained in the normal range. These results point to the need for further studies in larger groups of patients including those with cardiovascular disease and other comorbidities.

Keywords: Antibiotic; Amoxicillin and clavulanate; ECG; Heart rate; QTc.


Corresponding Author : Shambhulinga Purad