Teeth are a valuable source of DNA and resistant to adverse conditions such as incineration, immersion, trauma, mutilation, decompositionwhen compared to other parts of the body that are destroyed or degraded in mass disasters, so they are highly useful in forensic investigations. DNA profiling gives an exactidentification of culprits in crime scene investigations, identification of an individual in mass disastersas well as solving paternity issues. It also provides information regarding the physical characteristics, ethnicity and sex determination. The recent advancements in the technology of DNA research have revolutionized the field of forensic odontology and this paper provides an insight in to the recent concepts of DNA profiling in forensic dentistry.