Tuberculosis (TB) is a global public health problem, approximately 4, 00,000 people die from TB every year, more than 1,000 die every day and 100 million working days are lost. TB also remains as a major public health problem amongst the tribal population of this country. Studies show that socio-economic status, nutrition, family size, customs, beliefs and lack of medical facilities remain as concomitants to the high prevalence of TB among the tribal communities of this country. The study aims to investigate the incidence of tuberculosis (TB) with its nature and stigmatic affect on health. Researchers selected 100 households by purposive sampling method from Muria tribal community residing in Karmari village, Jagdalpur (Chhattishgarh) for study. A village-wise resource data were gathered through a structured schedule, interview, observation and focus group discussion. Further along with opinion of representatives and local leaders/ knowledgeable persons of village were also interviewed at the time from March to September, 2014. The findings of the study shows that in spite of various plans and programs and projects taken up by the government machinery, the result has been far from satisfactory. The knowledge about TB and its situation amongst Muria tribal population is scanty; due to isolation, illiteracy, socio-culture factors. Thus, there is a need to maintain and further strengthen TB control measures along with awareness and management of TB related stigma on a sustained and long term basis.