Objective: The objective of the study was to study the effect of 75 mg and 150 mg aspirin in prevention of pre-eclampsia in women with previous history of pre-eclampsia.

Method: This prospective interventional study was carried out in the Department of Obstetrics and Gynecology, Pt. B.D. Sharma PGIMS, Rohtak from 2019-2020. Women with previous history of pre-eclampsia who presented at period of gestation less than 16 weeks were included in the study. The patients were divided in two groups, Group-I: 50 patients who received aspirin, 75 mg daily and Group-II: 50 patients who received aspirin, 150 mg daily.

Results: Group I (75 mg of aspirin) and Group II (150 mg of Aspirin) were comparable with respect to age, education and socio-economic status. The mean gestational age of delivery was also comparable. Overall Incidence of pre-eclampsia in present study was 14%. Pre-eclampsia occurred in 8 (16%) women in group-I and 6 (12%) women in group-II. The difference was found to be statistically insignificant. Perinatal complications like low birth weight, preterm delivery, NICU transfer, respiratory distress syndrome and fetal growth restriction were not significantly different in both the groups.

Conclusion: There is no correlation between 75 mg versus 150 mg dose of aspirin and the incidence of pre-eclampsia in women with previous history of pre-eclampsia. Also, 150 mg aspirin had no statistically significant effect on the incidence of secondary outcome (Abruptio placenta, any maternal morbidity, fetal outcome intrauterine growth restriction, intrauterine death, NICU admission, NICU stay and perinatal death) in comparison to 75 mg aspirin.