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DOI: DOI: http://dx.doi.org/10.21088/ijmfnm.2347.999X.9222.3

Abstract

Persistent pulmonary hypertension of the newborn (PPHN) is a clinical syndrome of failed circulatory adaptation at birth, seen in about 2/1000 live born infants. While it is more commonly encountered in term and near term babies, it can be recognized in some premature babies with respiratory distress or bronchopulmonary dysplasia. Most commonly, PPHN is secondary to delayed or impaired relaxation of the pulmonary vasculature associated with diverse neonatal pulmonary pathologies such as meconium aspiration syndrome, congenital diaphragmatic hernia and respiratory distress syndrome.

Keywords : PPHN; Neonate; Systemic vascular resistance(SVR); Pulmonary vascular resistance(PVR); ECMO; Inhaled no; Sildenafil; Milrinone.

Corresponding Author : Shreya Bhate, Junior Resident Department of pediatric, Dr vitthalrao vikhe patil foundations medical College and hospital, Ahmednagar 414111, Maharashtra, India.shreyabhateb195@gmail.com