Neonatal infections represent an important cause of morbidity and mortality in neonatal period. NICU patients are at increased risk of neonatal infections because of poor intra-partum and postnatal infectioncontrol practices and also having poor immune defence mechanism. Sepsis is characterized by lethargy, poor feeding, fever or hypothermia and various nonspecific features. Sepsis screen is useful for diagnosis. Blood culture is gold standard. Simple hand washing is a good effective measure to reduce sepsis. 

Keywords: Neonatal infection; Hand washing; Sepsis screen.