The plants and its products are extensively used as source of medicines in Ayurveda, Siddha and traditional Chinese medicine. Even though rarely reported, adverse effects do occur with these types of medications. We report here an interesting case of AKI and hypokalaemia due to Kooshmandaswarasa ghrutham containing Benincasa Cerifera, Glycyrrhiza glabera and cow’s ghee which was used for epilepsy. The Glycyrrhiza glabera, containing glycyrrhizin is the most likely culprit for causing AKI. Keywords: Glycyrrhiza glabra; Licorice; Glycyrrhizin; AKI; Hypokalaemia