Objective: To explore the relationship of quality of life and depression in type 2 diabetic patients in comparison with healthy individuals (controls). Methodology: The present study was case control study. The data was collected from SVIMS Hospital in Tirupati, during DEC 2016 to JAN 2016. There were 80 participants including 40 type 2 DM patients whilst for a comparative assessment a group of 40 healthy individuals (age and sex matched) were also selected as a controls to meet the purpose of the study. subjects age range was set between 35­65 years. The study sample comprised of type 2 DM patients. While inclusion criteria the type 2 DM patients with duration of 5 years and above attending OPD, were selected as a cases and healthy individuals were selected as a controls. Sample was selected by simple random sampling technique using random number generated in Ms excel. WHO quality of life scale (QOL BREF) by Frisch 1994 and Beck depression inventory (BDI­II) developed by Aeron Beck in 1996 were used for data collection . The data was interpreted through SPSS­20. Results: The study findings showed a significant but negative between quality of life and depression scores. Good quality of life was negatively correlated in comparison to the depression in diabetic patients(r=0.567++ <.01). It was also discovered that there were significant differences present in depression and quality of life scores of diabetic people and healthy individuals. It was also indentified that there was significant difference among educational status, occupational status and type of diet, marital status, living status , monthly income with respect to mean scores of QOL at p­<0.05 level and there were significant difference among education status, occupational status and type of diet with respect to mean scores of depression at , 0.05 level. conclusion: Higher depression scores in BDI scores and lower scores of quality of life scores were seen in majority of the type 2 DM patients during the study. 

Keywords: Diabetes Mellitus (DM); Type 1 Diabetes Mellitus ; Type 2 Diabetes Mellitus.