Introduction: To study the spectrum of histopathological changes in liver with an emphasis on the rare incidental lesions of liver in autopsies. Methods: A retrospective study of medicolegal autopsies for six years was conducted in the Department of Pathology, JSS Medical College, Mysuru, Karnataka. The gross and microscopic findings of liver specimens were taken into consideration to establish the presence of liver diseases and also to find out the types of liver diseases in relation to the age and sex of the cases. Results: The present study consists of a series of 284 autopsy cases from JSS Hospital, Mysuru, conducted over a period of six years. A total of 121 liver specimens sent were studied, out of which 16(13.2%) were normal and 8(6.6%) were autolysed. Histopathological lesions were seen in 97(80.1%) liver specimens, out of which 46(47.4%) showed fatty change, 9(9.3%) cases showed chronic venous congestion along with 8(8.2%) cases of cirrhosis, 3(3.1%) cases of hepatitis and 8( 8.2%) cases of interesting fortuitous findings comprising of Dubin Johnson syndrome, von Meyenburg complex, large bile duct obstruction, metastatic deposits of carcinoma of cervix, neuroendocrine tumor, vaso­occlusive  sickle cell crisis, amebic liver abscess and tuberculosis with coexistent fatty change. Conclusion: Fatty change of liver was the commonest incidental pathologic finding of liver with the commonest age group for liver disease being 41­60 years. This study has contributed a handful of findings to the pool of rare liver lesions in pathology emphasising the indispensible contribution of autopsy to the knowledge of pathology.

Keywords: Autopsy; Dubin Johnson Syndrome; Incidental; Vaso Occlusive Sickle Cell Crisis; Von Meyenberg Complex.