Context: Papulosquamous lesions of skin are the most frequently seen conditions encountered by both dermatologists and pathologists. These conditions have a similar clinical picture; hence a definite histopathological diagnosis can solve the overlapping clinical features of various papulosquamous lesions of skin. Aims: To study the histopathological features of various subcategories of papulosquamous skin lesions and to assess the correlation between clinical diagnosis provided and the histopathological diagnosis obtained. Settings and Design: The study is done in a Tertiary care hospital which includes 150 skin biopsies received from Department of Dermatology. Methods and Material: The skin biopsy specimens were subjected to formalin fixation and paraffin embedding followed by staining with hematoxylin and eosin. The histopathological features of various papulosquamous lesions were analysed and clinicopathological correlation was done for the 150 cases of skin biopsies which were clinically suspected/ diagnosed as papulosquamous skin lesions. Statistical analysis used: Universal sampling done and this is a clinico-histopathological correlative study done for a period of 18 months. Results: Out of the 150 skin biopsies of papulosquamous lesions, psoriasis turned out to be the most common lesion. The papulosquamous skin lesions were commonly seen in males. 28% cases were of psoriasis vulgaris and 25% cases were of Lichen planus occupying the top two commonest papulosquamous skin lesions and a positive correlation with histopathological diagnosis turned out to be 76%. Conclusions: The complexity in diagnosing papulosquamous lesions due to features of clinical overlap can be overcome by the histopathological examination and findings which helps to diagnose the various subcategories of papulosquamous skin lesions.

Keywords: Papulosquamous lesions; Psoriasis; Lichen planus.