Context: Hepatitis B virus infection is a global health problem. Centre for Disease Control and prevention recommends vaccination for all health care workers. Protection statuses of vaccinees need to be assessed by measuring anti- Hepatitis B surface antigen level in the serum.

Aims: This study aims to detect the serum levels of anti-Hepatitis B surface antigen level among vaccinated health care workers of our Institution.

Settings and Design: Cross-sectional study

Methods and Material: This study included 93 heath care workers (surgeons, physicians, dentists, medical students, nurses, laboratory technicians, blood bank personnel and hospital attendants) of our tertiary care hospital for testing of anti-Hepatitis B surface antigen level; liver function tests were also done for the participants.

Statistical analysis: Data analysis was done using statistical package for social sciences version 22. Percentages were calculated for categorical variables, Chi-square test was used for comparison of proportions. Logistic regression analysis was performed for studying the factors influencing response to vaccine.

Results: In the present study, it was observed that about 9.7% were nonresponders, 21.5% were poor responders and the rest (68.8%) were responders.

Conclusions: All vaccinated individuals cannot be presumed to be fully protected. It is imperative to
test the anti-Hepatitis B surface antigen level of the individual after completing the course to decide on appropriate measures to be taken.

Keywords: Hepatitis B Surface Antigen; Heath Care Workers; Responders; Vaccinees.