Introduction: Negative Pressure Wound Therapy (NPWT) is now an established modality of treatment used to treat various complex acute and chronic wounds in all surgical fields. However in treatment of wounds with external fixators, creation and maintenance of an air tight seal using conventional adhesive dressings is usually cumbersome and not effective. We present a simple, novel, cost effective technique of NPWT application using sterile cellophane dressing for wounds with external fixators. Material and methods: We present a series of 15 patients where NPWT was applied using sterile cellophane (cling wrap). All wounds with external fixators not amenable to skin grafting or flap in the primary setting were included. Sponge based continuous NPWT was used. The end point of NPWT was achieving healthy granulation tissue for wound cover. Result: All patients were successfully treated with NPWT. The mean duration of NPWT application was 15days. Healthy granulation tissue and wound contraction was noted in all patients making wounds amenable for cover. Conclusion: NPWT using cellophane is simple, cost effective and can be easily used to treat wounds with external fixators.