Cross leg flap is a conventional flap for lower limb defects for long years where the local flap and free flap is not possible in the patient. The raw area created after raising the cross-leg flap in the donor leg was grafted with split skin graft. Split skin graft is a type of graft that contains epidermis and a portion of dermis and is commonly used to cover a raw area following trauma. Split skin grafts are commonly done in India following road traffic accidents to cover the affected site and raw area of the donor site of the flap. Split thickness grafting depends upon the raw area environment for its uptake and effective procedure. Autologous platelet rich plasma is an effective way to improve the graft take and survival. It contains growth factors which improves the proliferation and also has properties to improve blood supply. Autologous platelet rich plasma was also used to inject in the flap distal site in the cross-leg flap to increase the vascularity of the flap. In this case report we highlight the role of Autologous platelet rich plasma in the cross-leg flap and application of skin graft in the donor site of the cross-leg flap.