Osteoarthritis of the knee joint is the most common form of arthritis that cause pain, stiffness and decreased function. It is one of leading cause of disability in the Indian population. Many different methods are available to help the patients relieve their symptoms. Intra-articular steroid is one of them which is widely being used, but it has its own side effects. Further more, these treatments are generally intended to decrease pain, maintain or improve joint function and minimize disability but fail to regenerate the articular cartilage. Recent studies suggest an intra-articular injection of autologous PRP as an effective and safe biological treatment method in the initial stages of knee osteoarthritis.