Fragility fractures are lesions due to mechanical stress or trivial trauma which are not ordinarily resulting in fracture. The incidence of osteoporosis increasing day by day and now it is the most common metabolic disorder. Overt or subclinical thyroid dysfunction, renal dysfunction, post-menopausal women, ovarian failure, pregnancy, diabetes, hypertension and heart disease may increase the risk of fragility fractures. Thyroid hormone replacement stimulates calcium absorption and bone maturation, but recovery may be incomplete dependent on the duration and severity of hypothyroidism before treatment. Recent studies have demonstrated that the prevalence of fracture is high even in early stages of chronic kidney disease, including in those with age-associated renal impairment and leads to renal osteodystrophy which subsequently leads to osteoporosis. It’s a case of 36yrs old young pregnant women carrying twin babies of 35weeks 6days primigravida who underwent In Vitro Fertilization due to premature ovarian insufficiency had a history of trivial trauma due to pre-eclampsia induced seizure and sustained right proximal humerus and left acetabulum fracture with ongoing treatment for hypothyroidism and renal osteodystrophy.

Keywords: Fragility; Fractures; Osteodystrophy; Hypothyroidism.