Background: Diabetes increases the risk of co morbid depression almost twice which increases diabetic complications leading to poor metabolic control and decreased quality of life. Depression exacerbates the progression of diabetes and hence screening and treatment of depression in diabetic individuals helps in improving the glycemic control and quality of life.

Aims and objectives: Aim of this study is to determine the effects of metabolic control on depression and health related quality of life.

Materials and Methods: Case-control study design with 110 diabetic individual more than 5 years duration and 110 good controlled diabetic individuals. Glycemic index (HbA1C) is used for evaluating metabolic control. Hamilton’s scale of depression and anxiety is applied along with hospital anxiety and depression scale {HADS}. Unpairedstudent ‘t’ test is used to find the significance of values between the cases and controls.

Results: The mean Hamilton’s scoring for cases is 22.11±6.68 and for controls is 2.45±4.32. The difference is significant at p<0.05. The mean HADS score for cases is 11.51±4.5and for controls is 1.58±1.92. Its significant at p<0.05. 

Conclusion: This study found that the diabetes with poor glycemic control has more risk of co morbid depression and poor quality of life when compared togood glycemic controlled diabetics.

Keywords: Depression; Diabetes Mellitus; Glycaemic Index.