The objective of this short communication was to provide evidence for cause-effect inter-relationship and action-reaction association between Endoplasmic reticulum stress (ERS) and Peripheral Neuropathy along a structure-function continuum. ERS layed an important role in pathogenesis of rediabeticand diabetic neuropathy, bortezomib-induced peripheral neuropathy and Familial amyloid polyneuropathy. Whilst the existing evidence confirmed the presence of ERS in peripheral neuropathy, the ERS-based interventions had mixed results.

Keywords: Endoplasmic reticulum stress; Peripheral neuropathy; Neurophysiology; Molecular neurology.