Skin is a composite organ with functional coordination between various cell types. Trauma injuries disrupt the skin architecture and in response to the injury, fibroblasts, macrophages, platelets, keratinocytes mobilize to seal the damage. However, in many cases, trauma causes a serious problem. Effective chronic non-healing wounds in burns are still a challenge. There is no infallible solution available that can overcome the various complexities in burn wound healing and its management. Hence, there is a need to develop suitable technologies that could solve burn wound related complexities. An ideal intervention for wound care must involve components that act at different steps in the process of burn wound healing. In this article, we would like to review the role MMPs (Matrix Metalloproteinase in modulating the extracellular matrix proteins (ECM) proteins in burn wound healing. In addition, a clear understanding of molecular interaction among growth factors, cytokines, MMPs, and other ECM proteins may provide a suitable platform to bring precise solutions for the life of suffering burn patients. To build up a wide-scale for therapeutic strategies, co-stars of this review might help in aiming at stimulating the tissue regeneration process.