The mechanism of drug delivery has develops more competing and developed swiftly. Cost effective with increased efficacy have been integrated by various drug delivery arrangements. In spite of these technologies, the drug delivery systems lack to accomplish the requisite systemic circulation in control manner like Peptides and proteins. Conventional topical formulations have also many problems, such as establishment of active ingredient intense layer resulting irritation and allergic reactions etc. So predetermined delivery charge of active compound to target site develops into drug industry’s principal challenges. This review article focuses on the Novel approaches of product formulation like microsponge automation which entrap ingredient o, that to increase elegance and improved formulation elasticity and reduces its side effect. In extension, many studies share for microsponge systems as non- irritant, non-toxic prevents rapid and enormous growth of components inside the epidermis and the dermis. Thus Microsponges bear ynamic constituent having capably of least dose, with improved stability and modified drug discharge.

Keywords: Drug; Enhanced; Epidermis; Microsponge; Stability; Topical.