The new dithio carbamate derivatives, 2- (naphthalen-8-ylcarbamoyl)-1-(4-hydroxyphenyl) ethyl diethylcarbamodithioate (IIIa) and 2- (naphthalen-8-ylcarbamoyl)-1-(2,4-dichlorophenyl) ethyl diethylcarbamodithioate (IIIa) were synthesized from 1-naphylamine chalchone. The new molecules were characterized by spectral and elemental analysis data. The synthesized analogues ere evaluated for anti-mitotic activity by Bengal gram seed germination model showed strong to moderate activities compared with control. Both the molecules showed good inhibition.

Keywords: Dithiocarbamates; 1-Naphthalamine; Antimitotic Activity.