Objective: To investigate Antihypertensive efficacy of Carvedilol and its influence on blood glucose and lipid profile in patients of stage 1 hypertension.

Materials and Methods: Total of 60 patients were enrolled in the study, randomly allocated into two groups, group A and group B with 30 patients, group A received Metoprolol 25mg  twice daily and group B received Carvedilol 12.5mg twice daily, reduction in blood pressure compared at 12 and 24weeks, effect on fasting blood glucose and lipid profile compared at 24th week, Statistical analysis was done using paired and unpaired t test and data is presented as mean±SD.

Results: Mean SBP reduction with Carvedilol is 23±6.16 mmHg with no significant difference (p>0.05) compared to Metoprolol group (20.13±5.73), Mean DBP reduction with Carvedilol is 9.93±1.349 with no significant difference (p>0.05) compared to Metoprolol group (8.87±2.148) at 24th week of the study. Metoprolol showed a significant (p<0.05) elevation on Fasting blood sugar, Serum total cholesterol,LDL,VLDL and serum triglycerides, when compared with Carvedilol at the end of the study.

Conclusion: Result of the study shows that Carvedilol and Metoprolol are equally effective in reduction of blood pressure and Carvedilol has added advantage in less elevation of fasting blood glucose, serum total cholesterol, LDL, VLDL and serum triglycerides and which is an advantage to the hypertensive patients with lipid disorder and impaired glucose tolerance. 

Keywords: Carvedilol; Metoprolol; Lipid Profile; Hypertension; Fasting Blood Glucose.