Pharmaceutical industries are now focused towards research and development of new drug delivery technologies to fulfill the needs of the modern world. Innovations with lipid based drug delivery have become a vital component of development in dosage form. Many formulations and innovations in controlled and targeted drug delivery have been attempted for the release of drug at the right place in a safe and reproducible manner. Liposomal drug delivery systems has become successful and has led to many development in liposome based formulations like niosomes, ethosomes, transferosomes, bilosomes, etc. Bilosomes are colloidal novel drug delivery systems similar to other liposomal delivery systems but prepared by incorporating bile salts into the lipid bilayer membrane. This present article focuses on the bilosomal drug delivery systems.