The purpose of this research work is to formulate and evaluate the Orodispersible drug delivery system of already used therapeutic molecule to enhance bioavailability and effectiveness of the drug. Among ODT drugs, the most promising antiemetic is Ondansetron hydrochloride and it was selected for the present study. Thus the objectives of the drug work were to formulate and evaluate Orodispersible tablets of Ondansetron hydrochloride, having adequate mechanical strength, rapid disintegration and fast action. Pre-compression parameters like angle of repose, bulk density, tapped density, compressibility index & post compression parameters like wetting time, water absorption ratio, in-vitro disintegration and in-vitro dispersion time were studied. The hardness, friability and drug content of all the formulations were found to be with in the limits. The best formulation F10 have shown good disintegration time, dissolution time and dispersion time. The best promising formulation were also being found to be stable at 40°C±75%. Finally the in-vitro drug released characteristics of best formulation was compared to commercial formulation.