1Senior Resident, Department of Skin and VD, Rajasthan University of Health Science, Jaipur 302033, Rajasthan, India, 2,3Professor, Department of Skin and VD, Mahatma Gandhi Medical College, Jaipur 302039 Rajasthan, India, 4Senior Resident, Sheehd Hasan Khan Mewati Government Medical College, Haryana 122107, India.
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Checkpoint inhibitors targeting CTLA4 (Cytotoxic T-lymphocyte antigen-4), PD-1 (programmed death)1 on lymphocytes and PD-L1 (programmed death ligand)1 on tumors cells are novel and promising treatment options for different types of cancer. But these agents are double edged swords, they undoubtedly robust the anti-tumor response but also throttle up the normal immunologic homeostasis. Autoimmune adverse reactions are very common with checkpoint inhibitors. We present a case of bullous pemphigoid, as an adverse reactions to Avelumab treated urinary bladder cancer with liver metastasis.
Corresponding Author : Divya Yadav, Senior Resident, Department of Skin and VD, Rajasthan University of Health Science, Jaipur 302033, Rajasthan, India.