An autogenous formalin killed vaccine was prepared from the collected wart samples. The formalin inactivated autogenous vaccine was adjuvented with equal volumes of aluminium hydroxide. After sterility check up the vaccine was administered to both the animals subcutaneously, cow @ 10ml and heifer calf 5ml on 0 day and then subsequently 10 days interval. The regression of the warts was started by three weeks of post vaccination and complete regression was appeared by sixth week in less severe case of heifer calf and in cow seventh week. The study represents successful management of bovine papillomas with a bovine specific autogenous vaccine. Further the autogenous vaccine prepared from one animal treated successfully to another animal.