The present study was undertaken to study the immunomodulatory effect of Zinc Sulphate  in  layer chicks by monitoring the specific immunological responses,  to New Castle Disease and Infectious Bursal Disease Vaccines, Three groups of experimental chickens comprising of 20 chicks were taken  in which, first two groups of chicks were inoculated twice with Live Newcastle Disease and Infectious Bursal Disease antigens intra occularly. The chicks of group I served as Vaccinated and II group vaccinated with Zinc Sulphate as supplement while group III experimental birds served as Unvaccinated control. At the termination of experiment, the order of seroconversion to inoculated antigens i.e. New Castle Disease and Infectious Bursal Disease were II>I>III and II>I>III while in Total Protein and Globulin levels, Net body gains and Phagocytic Index were II>I>III respectively. Challenge studies were conducted on experimental chicks employing Virulent New castle Disease Virus and Virulent E.Coli (078 serotype) to study the specific and non- specific immune responses respectively. The results indicated better survival/protection rates for Zinc Sulphate treated chicks followed by that of vaccinated group and Unvaccinated chicken groups. It is concluded that Zinc sulphate is more efficient immunomodulator in evoking specific as well as non specific immune responses in layer chicks. So, Zinc Sulphate can be recommended in field use for enhancing the immunological responses besides net body weights in layer chicks along with the Scheduled vaccination programmes.