Background: An extremely common, chronic, and frequently disabling condition of the gutbrain connection, is irritable bowel syndrome (IBS). It is characterised by recurring stomach pain and changes in bowel habits. Grahani is the seat of Jatharagni and Grahani Dosha is one among the Mahagadas. Grahani is a disease of great clinical relevance in today's modern era because of its direct link with the improper food habits and stressful lifestyle of the present time. Vitiation of Agni affects the digestion process and vitiates proper formation of further dhathus, so one should give importance to the management of Agni.

Aim: Ayurveda described various treatment modalities for the management of Grahani Roga. In this article we tried to summarized the effect of Takra (buttermilk) in Grahani Roga with the help of Ayurvedic principles and pharmacodynamics.

Methods and Materials: Various Ayurvedic texts like Charaka Samhita, Susruta Samhita, AstangHridya and relevant modern medical science books.

Conclusion: Shamana and Shodhana chikitsa modalities are adopted to treat Grahani but diet and lifestyle are the most important modalities to be followed to control or cure the condition. Takra is compared with Amrita because of its qualities. Acharya Vagbhata states that Takra does Srotoshodhana and helps the rasa to reach the srotas. Takra by its different gunas acts as tridosha shamaka, it is very helpful in the patients suffering from agni vikriti have different types of dosha dushti.