There have been increasing numbers of applications using saliva, as the target substrate for performing clinical diagnostic tests. These have focused primarily on point-of-care testing. These point of care testing approaches range from, for example, currently available, highly specialized screening tests for the presence of antibodies recognizing HIV to the potential development of “lab-on-achip” platforms. Sampling of saliva is advantageous, since non-invasive, stress free, easy and frequent collections are possible. Apart from acting as first time of defence against foreign pathogenic, it also constantly cleanse and lubricate the oral cavity. Number of biochemical, immunological, toxicological and microbiological analysis are possible in saliva and importance of oral tissues evaluation and neoplasm screening how long been established also, saliva is routinely referenced in forensic odontology and toxicology especially in drug abuse and alcoholism.This can become a non-invasive alternative to blood & urine test, for early disease detection and management in future.

Key words Saliva, clinical diagnostic test, lab on chip