Penile cancer is an aggressive disease and in patients with advanced or metastatic disease, it is virtually incurable. While this squamous cell cancer responds to chemotherapy, successful treatment of lymphatic metastases can only be achieved with aggressive surgical treatment in combination with chemotherapy. Since penile carcinoma is relatively rare, there is a paucity of clinical data as well as literature on the chemotherapeutic management of this aggressive disease. Recent advances have included the establishment of less toxic regimens incorporating taxanes, while cisplatinum remains central to all regimens. Multi-institutional studies would advance the information regarding multimodal care for patients with penile cancer. We report a case of a 76 year old male presenting with an advanced loco-regional penile cancer.

Keywords: Biologic agents; chemotherapy; combined modality therapy; penile cancer.