Aim: Breast cancer is the most common cancer among women worldwide and also in India. Patients with same diagnosis have different clinical outcomes and prognosis. This study aimed to evaluate molecular classification in Indian population along with various parameters like tumor grade, tumor histology, age, site, menopausal status and metastasis at the time of presentation. Methods: In this retrospective, single institutional study, we included 429 patients, who underwent immunohistochemistry (IHC) markers for ER, PR, HER2 and further subclassified as per molecular classification into subtypes and their relation with other parameters was studied. Results: This study revealed 39.62% Luminal A, 16.31% Luminal B, 27.03% Basal and 17.01% Her 2 Enriched subtypes with less hormone positivity in Indian population. Conclusion: Our results of molecular classification are consistent with other Indian studies but quite different from western studies. Triple negative breast cancer is slightly more in Indian population going towards poor prognosis and increased probability of metastasis.

Keywords: Breast; Epidemiology; Receptor; IHC; Central India.