Objective: To evaluate the diagnostic success and rates of complications of computed tomography (CT)-guided percutaneous biopsy of bone lesions suspected for malignancy. Materials and methods: The one-year prospective study considered 20 cases undergoing CT-guided percutaneous biopsies of bone lesions. All the specimens were obtained with either 11 gauge or 18-gauge needles for bone biopsy and soft tissue biopsy, respectively. The data related to demographics, lesions and histopathological results were collected and analyzed. The biopsy findings were corroborated with the final diagnosis of the clinicians to verify the accuracy of the procedure. The percentage of diagnostic positive yield with CT-guided percutaneous biopsy was analyzed for all the selected cases. Results: The mean age of the study participants was 45.0 ± 28 years and 55% of them were men. Based on the biopsy findings, 12 subjects were diagnosed with primary tumors (60%) and 3 with metastasis (15%). The result was inconclusive for 5 (25%) subjects. Long bones (35%) were found to be the most common site for bone metastasis followed by spine (30%) and hip (25%). Complications were not encountered in any of the cases. Corroboration of the biopsy findings demonstrated that CT-guided percutaneous biopsy was 95% accurate in diagnosing the bone lesions. Conclusion: CT-guided percutaneous biopsy is a safe and effective procedure for the diagnosis of suspicious bone lesions.

Keywords: CT; Percutaneous; Biopsy; bone lesions; Malignancy; Cancer